There are, of course, many things and situations in this world for one to desire or aspire after. The resulting karma of acquiring or achieving anything here, comes to pass in various ways. It can certainly be said ...and... here I speak as a voice of experience on the subject, a significant majority of the things and situations we can desire or aspire after here are not worth the getting. Disappointment can be a significant feature of karma and so can Regret and 20/20 hindsight. I believe another byproduct of Karma is; 'live and learn'... alternatively... 'don't live and don't learn'. Both of these occur with regularity.
In the end... life wears almost everyone down. We wear the marks of our struggles and those marks are what? They are the scars of the effort expended by the separated self, in its pursuit of personal desires and aspirations in this world, which also brings one into conflict with every other competing interest. THIS is SELF EVIDENT, unless you are not yourself. If you are not yourself, everything is seen through the lens of false-self interest. It makes sense (whatever 'it' is)... in THAT THEATER of enterprise.
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